GYOFIL AB

GYOFIL  AB  particles are sterile medicated type I collagen particles combined with the most trusted topical antibiotic Mupirocin 2% USP and Metronidazole 1% IP. GYOFIL AB particles are effective in hastening the healing process by formation of early granulation tissue and wound contraction. So  that, the number of debridements and dressings required can be reduced. Collagen keeps the skin moist. Mupirocin and Metronidazole are antibiotics that kill bacteria and other infection-causing microorganisms by destroying the DNA and bacterial cell membrane.

Type I Collagen particles:

The most abundant of all three collagen types. It is the dominant constituent, occupying more than  90% of the tissue and is the most commonly used collagen in the wound healing process. In addition to the skin, it can also be found in tendons, ligaments, bone, teeth and scar tissue.

• GYOFIL AB particles have high surface area allowing them to effectively penetrate and deliver the maximum amount of GYOFIL AB into the wound surface area.
• GYOFIL AB particles are 100% non-hydrolyzed type 1 bovine native collagen.
• GYOFIL AB particles protects and retains significantly more native triple helical protein structure, thus allowing superior stability of the molecule and scaffolding through all four phase of wound healing
• GYOFIL AB particles, a key component of the extracellular matrix, plays critical roles in the regulation of the phases of wound healing either in its native, fibrillar conformation or as soluble components in the wound milieu.
• GYOFIL AB particles plays an important role in all phases of wound healingdue to its chemotactic nature, which attracts fibroblasts to the wound site.
• GYOFIL AB particles supports new blood vessel formation, granulation tissue formation, the debridement of the wound and the ability of the wound to re-epithelize.
• Dressing with GYOFIL AB particles assures having collagen-building amino acids circulating around the damaged tissue. This has been shown to enhance healing process faster.

Mupirocin:

• The name reason based on the biosynthesis of Mupirocin, MuP (Mutant of Pseudomonas) + iro (oxiro) + cin (carboxylic acid) = MUPIROCIN.
• It is an alpha, beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxygroup of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid.
• Mupirocin is also called as Pseudomonic acid which was isolated, purified, and characterized by A. T. Fuller and co-workersin 1971.It is called as Pseudomonic acid because it is derived from submerged fermentation of Pseudomonas fluorescens.
• Mupirocin inhibits bacterial RNA and protein synthesisby specific irreversible binding to bacterial isoleucyl tRNA synthetase, which catalyzes the formation of isoleucyl tRNA from isoleucine and tRNA. This prevents incorporation of isoleucine into protein chains, leading to arrest of protein synthesis.

Metronidazole:

• Chemically metronidazole is Methyl-nitro-imidazole derivative.
• Metronidazole gel significantly decreases the anaerobic organism colonisation of woundsand helps maintain a moist wound environment.
• Generally, topical metronidazole is also reported to result in a reduction or eradication of wound odor, decrease in wound drainage, improvement in wound appearance, decrease in surrounding cellulitis, halting of tissue necrosis, and decrease in pain.
• Metronidazole diffuses into the organism, inhibits protein synthesis by interacting with DNA, and causes a loss of helical DNA structure and strand breakage. Therefore, it causes cell death in susceptible organisms, thus they act as bactericidal and antimicrobial agents

Indications:

• Diabetic foot ulcers
• Venus leg ulcers
• Pressure ulcers
• Chronic infected wounds
• Tunneled and Undermined wounds

Presentation:

• Available in 5 ml pack